Gabapentin Combined With Naltrexone for the Treatment of Alcohol Dependence

Raymond F Anton, Hugh Myrick, Tara M Wright, Patricia K Latham, Alicia M Baros, L Randolph Waid, Patrick K Randall American Journal of Psychiatry 2011, 168 (7): 709-17 OBJECTIVE: Naltrexone, an efficacious medication for alcohol dependence, does not work for everyone. Symptoms such as insomnia and mood instability that are most evident during early abstinence might respond better to a…

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Opioid Use and Dropout in Patients Receiving Oral Naltrexone With or Without Single Administration of Injection Naltrexone

Maria A Sullivan, Adam Bisaga, Andrew Glass, Kaitlyn Mishlen, Martina Pavlicova, Kenneth M Carpenter, John J Mariani, Frances R Levin, Edward V Nunes BACKGROUND: Adherence to oral naltrexone has been poor and can be improved somewhat with behavioral therapy. We compared behavioral naltrexone therapy (BNT) to compliance enhancement (CE) and tested efficacy of single-dose injection naltrexone (XR-NTX; 384 mg) with…

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Reductions in Alcohol Craving Following Naltrexone Treatment for Heavy Drinking

Amy W Helstrom, Frederick C Blow, Valerie Slaymaker, Henry R Kranzler, Shirley Leong, David Oslin AIMS: The role of craving for alcohol as a response to alcohol treatment is not well understood. We examined daily diary ratings of craving over the course of 28 days among individuals participating in an inpatient substance abuse treatment program. METHODS: Participants were alcohol dependent…

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Naltrexone: A Pan-Addiction Treatment?

Elias Aboujaoude, Wael O Salame CNS Drugs 2016 July 11   Addiction is a major public health problem with few efficacious and safe treatments. The goal of this review is to provide an evidence-based assessment of the therapeutic role of the opioid antagonist naltrexone across the addiction spectrum-substance-based and behavioral. The PubMed database was searched for randomized, placebo-controlled clinical trials…

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